CASZ1.H13RSNP.0.SGI.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CASZ1.H13RSNP.0.SGI.D
Gene (human)	CASZ1 (GeneCards)
Gene synonyms (human)	CST, SRG, ZNF693
Gene (mouse)	Casz1
Gene synonyms (mouse)	Cst, D4Ertd432e, Kiaa3026
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	26
Consensus	ndWTTTKSKbndWWWhnnbnndWWWb
GC content	37.05%
Information content (bits; total / per base)	14.308 / 0.55
Data sources	HT-SELEX + Genomic HT-SELEX + SMiLe-Seq
Aligned words	7351
Previous names

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
overall, 4 experiments	median	0.998	0.998	0.992	0.988	0.959	0.953
overall, 4 experiments	best	0.999	0.998	0.995	0.993	0.974	0.967
Lysate, 2 experiments	median	0.998	0.998	0.991	0.988	0.942	0.937
Lysate, 2 experiments	best	0.998	0.998	0.992	0.99	0.946	0.941
IVT, 1 experiments	median	0.997	0.995	0.991	0.987	0.974	0.965
IVT, 1 experiments	best	0.997	0.995	0.991	0.987	0.974	0.965
GFPIVT, 1 experiments	median	0.999	0.998	0.995	0.993	0.972	0.967
GFPIVT, 1 experiments	best	0.999	0.998	0.995	0.993	0.972	0.967

Genomic HT-SELEX benchmarking		Centrality	pseudo-auROC	auROC	auPR
overall, 4 experiments	median	426.98	0.905	0.934	0.913
overall, 4 experiments	best	676.456	0.915	0.956	0.932
Lysate, 2 experiments	median	549.029	0.901	0.939	0.918
Lysate, 2 experiments	best	676.456	0.91	0.956	0.932
IVT, 1 experiments	median	432.357	0.852	0.934	0.877
IVT, 1 experiments	best	432.357	0.852	0.934	0.877
GFPIVT, 1 experiments	median	132.022	0.907	0.934	0.917
GFPIVT, 1 experiments	best	614.585	0.915	0.944	0.922

SMiLE-Seq benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.625	0.595	0.579	0.563	0.544	0.54
Overall, 2 experiments	best	0.663	0.625	0.611	0.586	0.565	0.556

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Multiple dispersed zinc fingers {2.3.4} (TFClass)
TF subfamily	Unclassified {2.3.4.0} (TFClass)
TFClass ID	TFClass: 2.3.4.0.1
HGNC	HGNC:26002
MGI	MGI:1196251
EntrezGene (human)	GeneID:54897 (SSTAR profile)
EntrezGene (mouse)	GeneID:69743 (SSTAR profile)
UniProt ID (human)	CASZ1_HUMAN
UniProt ID (mouse)	CASZ1_MOUSE
UniProt AC (human)	Q86V15 (TFClass)
UniProt AC (mouse)	Q9CWL2 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	4 overall: 2 Lysate, 1 IVT, 1 GFPIVT
Genomic HT-SELEX	4 overall: 2 Lysate, 1 IVT, 1 GFPIVT
SMiLE-Seq	2
PBM	0

PCM	CASZ1.H13RSNP.0.SGI.D.pcm
PWM	CASZ1.H13RSNP.0.SGI.D.pwm
PFM	CASZ1.H13RSNP.0.SGI.D.pfm
Threshold to P-value map	CASZ1.H13RSNP.0.SGI.D.thr
Motif in other formats
JASPAR format	CASZ1.H13RSNP.0.SGI.D_jaspar_format.txt
MEME format	CASZ1.H13RSNP.0.SGI.D_meme_format.meme
Transfac format	CASZ1.H13RSNP.0.SGI.D_transfac_format.txt
Homer format	CASZ1.H13RSNP.0.SGI.D_homer_format_0.001.txt CASZ1.H13RSNP.0.SGI.D_homer_format_0.0005.txt CASZ1.H13RSNP.0.SGI.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1368.0	1669.0	2777.0	1537.0
02	1729.25	661.25	3508.25	1452.25
03	1258.0	164.0	563.0	5366.0
04	536.0	5.0	19.0	6791.0
05	172.0	46.0	10.0	7123.0
06	23.0	111.0	0.0	7217.0
07	384.0	254.0	4165.0	2548.0
08	768.0	1071.0	4922.0	590.0
09	125.0	667.0	5767.0	792.0
10	436.0	1297.0	3794.0	1824.0
11	1291.0	2240.0	2124.0	1696.0
12	3112.0	775.0	2327.0	1137.0
13	4336.0	253.0	1163.0	1599.0
14	4502.0	107.0	258.0	2484.0
15	3946.0	142.0	160.0	3103.0
16	2558.0	791.0	469.0	3533.0
17	1884.0	1843.0	1815.0	1809.0
18	1127.0	1817.0	2454.0	1953.0
19	1020.0	1707.0	3277.0	1347.0
20	1142.0	1932.0	2636.0	1641.0
21	1780.0	1336.0	2474.0	1761.0
22	2210.0	560.0	1799.0	2782.0
23	2260.0	225.0	509.0	4357.0
24	1588.0	263.0	297.0	5203.0
25	1121.25	514.25	337.25	5378.25
26	927.0	1419.0	1317.0	3688.0

PFM

	A	C	G	T
01	0.186	0.227	0.378	0.209
02	0.235	0.09	0.477	0.198
03	0.171	0.022	0.077	0.73
04	0.073	0.001	0.003	0.924
05	0.023	0.006	0.001	0.969
06	0.003	0.015	0.0	0.982
07	0.052	0.035	0.567	0.347
08	0.104	0.146	0.67	0.08
09	0.017	0.091	0.785	0.108
10	0.059	0.176	0.516	0.248
11	0.176	0.305	0.289	0.231
12	0.423	0.105	0.317	0.155
13	0.59	0.034	0.158	0.218
14	0.612	0.015	0.035	0.338
15	0.537	0.019	0.022	0.422
16	0.348	0.108	0.064	0.481
17	0.256	0.251	0.247	0.246
18	0.153	0.247	0.334	0.266
19	0.139	0.232	0.446	0.183
20	0.155	0.263	0.359	0.223
21	0.242	0.182	0.337	0.24
22	0.301	0.076	0.245	0.378
23	0.307	0.031	0.069	0.593
24	0.216	0.036	0.04	0.708
25	0.153	0.07	0.046	0.732
26	0.126	0.193	0.179	0.502

PWM

	A	C	G	T
01	-0.295	-0.096	0.412	-0.178
02	-0.061	-1.02	0.646	-0.235
03	-0.378	-2.404	-1.18	1.071
04	-1.229	-5.54	-4.462	1.306
05	-2.357	-3.642	-5.014	1.354
06	-4.29	-2.788	-6.717	1.367
07	-1.561	-1.971	0.817	0.326
08	-0.871	-0.539	0.984	-1.134
09	-2.672	-1.011	1.143	-0.84
10	-1.435	-0.348	0.724	-0.008
11	-0.353	0.198	0.145	-0.08
12	0.526	-0.862	0.236	-0.479
13	0.858	-1.975	-0.457	-0.139
14	0.895	-2.824	-1.956	0.301
15	0.764	-2.546	-2.429	0.523
16	0.33	-0.841	-1.362	0.653
17	0.025	0.003	-0.012	-0.016
18	-0.488	-0.011	0.289	0.061
19	-0.588	-0.074	0.578	-0.31
20	-0.475	0.05	0.36	-0.113
21	-0.032	-0.318	0.297	-0.043
22	0.184	-1.186	-0.021	0.414
23	0.207	-2.092	-1.281	0.863
24	-0.146	-1.937	-1.816	1.04
25	-0.493	-1.27	-1.69	1.073
26	-0.683	-0.258	-0.333	0.696

Standard thresholds

P-value	Threshold
0.001	3.35826
0.0005	4.46841
0.0001	6.75286