E2F4.H13INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F4.H13INVITRO.0.P.B
Gene (human)	E2F4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	15
Consensus	SGCGSSvvnddbnvv
GC content	59.65%
Information content (bits; total / per base)	7.744 / 0.516
Data sources	ChIP-Seq
Aligned words	550
Previous names	E2F4.H12INVITRO.0.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (56)	0.853	0.907	0.739	0.859	0.765	0.842	2.431	3.66	133.573	252.187
Mouse	12 (81)	0.837	0.885	0.718	0.789	0.723	0.803	2.121	2.732	96.886	269.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.727	0.711	0.721	0.704	0.708	0.689
Non-Methyl HT-SELEX, 2 experiments	best	0.957	0.925	0.944	0.909	0.919	0.881

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.563	0.079	0.259	0.18

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.4
HGNC	HGNC:3118
MGI	MGI:103012
EntrezGene (human)	GeneID:1874 (SSTAR profile)
EntrezGene (mouse)	GeneID:104394 (SSTAR profile)
UniProt ID (human)	E2F4_HUMAN
UniProt ID (mouse)	E2F4_MOUSE
UniProt AC (human)	Q16254 (TFClass)
UniProt AC (mouse)	Q8R0K9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 12 mouse
HT-SELEX	2
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	E2F4.H13INVITRO.0.P.B.pcm
PWM	E2F4.H13INVITRO.0.P.B.pwm
PFM	E2F4.H13INVITRO.0.P.B.pfm
Threshold to P-value map	E2F4.H13INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	E2F4.H13INVITRO.0.P.B_jaspar_format.txt
MEME format	E2F4.H13INVITRO.0.P.B_meme_format.meme
Transfac format	E2F4.H13INVITRO.0.P.B_transfac_format.txt
Homer format	E2F4.H13INVITRO.0.P.B_homer_format_0.001.txt E2F4.H13INVITRO.0.P.B_homer_format_0.0005.txt E2F4.H13INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	69.0	163.0	308.0	10.0
02	18.0	87.0	437.0	8.0
03	29.0	507.0	3.0	11.0
04	27.0	12.0	455.0	56.0
05	6.0	224.0	309.0	11.0
06	39.0	136.0	328.0	47.0
07	308.0	98.0	113.0	31.0
08	291.0	77.0	111.0	71.0
09	205.0	93.0	145.0	107.0
10	87.0	65.0	117.0	281.0
11	93.0	77.0	83.0	297.0
12	55.0	156.0	112.0	227.0
13	176.0	89.0	190.0	95.0
14	288.0	77.0	146.0	39.0
15	302.0	49.0	154.0	45.0

PFM

	A	C	G	T
01	0.125	0.296	0.56	0.018
02	0.033	0.158	0.795	0.015
03	0.053	0.922	0.005	0.02
04	0.049	0.022	0.827	0.102
05	0.011	0.407	0.562	0.02
06	0.071	0.247	0.596	0.085
07	0.56	0.178	0.205	0.056
08	0.529	0.14	0.202	0.129
09	0.373	0.169	0.264	0.195
10	0.158	0.118	0.213	0.511
11	0.169	0.14	0.151	0.54
12	0.1	0.284	0.204	0.413
13	0.32	0.162	0.345	0.173
14	0.524	0.14	0.265	0.071
15	0.549	0.089	0.28	0.082

PWM

	A	C	G	T
01	-0.678	0.168	0.8	-2.486
02	-1.961	-0.451	1.149	-2.676
03	-1.515	1.297	-3.414	-2.403
04	-1.582	-2.327	1.189	-0.882
05	-2.91	0.484	0.803	-2.403
06	-1.232	-0.011	0.863	-1.052
07	0.8	-0.334	-0.194	-1.451
08	0.744	-0.571	-0.211	-0.65
09	0.396	-0.386	0.053	-0.248
10	-0.451	-0.737	-0.159	0.709
11	-0.386	-0.571	-0.497	0.764
12	-0.899	0.125	-0.203	0.497
13	0.244	-0.429	0.32	-0.365
14	0.733	-0.571	0.059	-1.232
15	0.781	-1.012	0.112	-1.094

Standard thresholds

P-value	Threshold
0.001	4.99596
0.0005	5.65101
0.0001	6.97656