ESR1.H13RSNP.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H13RSNP.1.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	vTGACCYnv
GC content	58.74%
Information content (bits; total / per base)	10.151 / 1.128
Data sources	ChIP-Seq
Aligned words	1000
Previous names	ESR1.H12RSNP.1.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.83	0.906	0.709	0.849	0.794	0.873	2.311	2.785	161.161	408.77
Mouse	22 (29)	0.87	0.9	0.753	0.808	0.834	0.87	2.452	2.761	214.886	413.102

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.724	0.666	0.654	0.617	0.601	0.582
Non-Methyl HT-SELEX, 1 experiments	best	0.724	0.666	0.654	0.617	0.601	0.582

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.133	14.816	0.083	0.097

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	ESR1.H13RSNP.1.P.B.pcm
PWM	ESR1.H13RSNP.1.P.B.pwm
PFM	ESR1.H13RSNP.1.P.B.pfm
Threshold to P-value map	ESR1.H13RSNP.1.P.B.thr
Motif in other formats
JASPAR format	ESR1.H13RSNP.1.P.B_jaspar_format.txt
MEME format	ESR1.H13RSNP.1.P.B_meme_format.meme
Transfac format	ESR1.H13RSNP.1.P.B_transfac_format.txt
Homer format	ESR1.H13RSNP.1.P.B_homer_format_0.001.txt ESR1.H13RSNP.1.P.B_homer_format_0.0005.txt ESR1.H13RSNP.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	156.0	353.0	398.0	93.0
02	2.0	10.0	2.0	986.0
03	6.0	11.0	983.0	0.0
04	882.0	93.0	21.0	4.0
05	4.0	995.0	1.0	0.0
06	34.0	959.0	0.0	7.0
07	9.0	297.0	15.0	679.0
08	272.0	151.0	356.0	221.0
09	200.0	187.0	455.0	158.0

PFM

	A	C	G	T
01	0.156	0.353	0.398	0.093
02	0.002	0.01	0.002	0.986
03	0.006	0.011	0.983	0.0
04	0.882	0.093	0.021	0.004
05	0.004	0.995	0.001	0.0
06	0.034	0.959	0.0	0.007
07	0.009	0.297	0.015	0.679
08	0.272	0.151	0.356	0.221
09	0.2	0.187	0.455	0.158

PWM

	A	C	G	T
01	-0.467	0.343	0.462	-0.977
02	-4.213	-3.066	-4.213	1.367
03	-3.484	-2.985	1.364	-4.982
04	1.256	-0.977	-2.405	-3.783
05	-3.783	1.376	-4.525	-4.982
06	-1.952	1.339	-4.982	-3.362
07	-3.156	0.171	-2.711	0.995
08	0.084	-0.5	0.351	-0.122
09	-0.221	-0.288	0.596	-0.455

Standard thresholds

P-value	Threshold
0.001	4.494165
0.0005	5.80305
0.0001	7.772455