| Motif | FOXA2.H13RSNP.1.SM.B |
| Gene (human) | FOXA2 (GeneCards) |
| Gene synonyms (human) | HNF3B, TCF3B |
| Gene (mouse) | Foxa2 |
| Gene synonyms (mouse) | Hnf3b, Tcf-3b, Tcf3b |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | FOXA2.H13RSNP.1.SM.B |
| Gene (human) | FOXA2 (GeneCards) |
| Gene synonyms (human) | HNF3B, TCF3B |
| Gene (mouse) | Foxa2 |
| Gene synonyms (mouse) | Hnf3b, Tcf-3b, Tcf3b |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 16 |
| Consensus | dYMAATATTTAChYWn |
| GC content | 28.52% |
| Information content (bits; total / per base) | 17.643 / 1.103 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 5603 |
| Previous names | FOXA2.H12RSNP.1.SM.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 54 (310) | 0.752 | 0.83 | 0.576 | 0.683 | 0.748 | 0.874 | 2.307 | 3.059 | 46.502 | 130.538 |
| Mouse | 20 (114) | 0.741 | 0.822 | 0.569 | 0.68 | 0.685 | 0.816 | 1.982 | 3.027 | 53.571 | 130.854 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.983 | 0.977 | 0.941 | 0.925 | 0.866 | 0.847 |
| best | 0.994 | 0.993 | 0.955 | 0.946 | 0.874 | 0.862 | |
| Methyl HT-SELEX, 1 experiments | median | 0.994 | 0.993 | 0.955 | 0.946 | 0.874 | 0.862 |
| best | 0.994 | 0.993 | 0.955 | 0.946 | 0.874 | 0.862 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.972 | 0.961 | 0.926 | 0.904 | 0.858 | 0.833 |
| best | 0.972 | 0.961 | 0.926 | 0.904 | 0.858 | 0.833 | |
| rSNP benchmarking, ADASTRA | odds-ratio | -log-Fisher's P | Pearson r | Kendall tau |
|---|---|---|---|---|
| # | 6.437 | 29.025 | 0.236 | 0.215 |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.906 | 0.367 | 0.878 | 0.521 |
| batch 2 | 0.7 | 0.124 | 0.761 | 0.548 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Fork head/winged helix factors {3.3} (TFClass) |
| TF family | FOX {3.3.1} (TFClass) |
| TF subfamily | FOXA {3.3.1.1} (TFClass) |
| TFClass ID | TFClass: 3.3.1.1.2 |
| HGNC | HGNC:5022 |
| MGI | MGI:1347476 |
| EntrezGene (human) | GeneID:3170 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:15376 (SSTAR profile) |
| UniProt ID (human) | FOXA2_HUMAN |
| UniProt ID (mouse) | FOXA2_MOUSE |
| UniProt AC (human) | Q9Y261 (TFClass) |
| UniProt AC (mouse) | P35583 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 54 human, 20 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | FOXA2.H13RSNP.1.SM.B.pcm |
| PWM | FOXA2.H13RSNP.1.SM.B.pwm |
| PFM | FOXA2.H13RSNP.1.SM.B.pfm |
| Threshold to P-value map | FOXA2.H13RSNP.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | FOXA2.H13RSNP.1.SM.B_jaspar_format.txt |
| MEME format | FOXA2.H13RSNP.1.SM.B_meme_format.meme |
| Transfac format | FOXA2.H13RSNP.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1338.75 | 536.75 | 2979.75 | 747.75 |
| 02 | 226.0 | 2545.0 | 117.0 | 2715.0 |
| 03 | 3207.0 | 2026.0 | 120.0 | 250.0 |
| 04 | 5227.0 | 220.0 | 65.0 | 91.0 |
| 05 | 5410.0 | 103.0 | 36.0 | 54.0 |
| 06 | 0.0 | 60.0 | 0.0 | 5543.0 |
| 07 | 5371.0 | 0.0 | 232.0 | 0.0 |
| 08 | 0.0 | 0.0 | 0.0 | 5603.0 |
| 09 | 0.0 | 1.0 | 8.0 | 5594.0 |
| 10 | 3.0 | 1.0 | 2155.0 | 3444.0 |
| 11 | 4382.0 | 4.0 | 1216.0 | 1.0 |
| 12 | 97.0 | 5183.0 | 25.0 | 298.0 |
| 13 | 2649.0 | 639.0 | 588.0 | 1727.0 |
| 14 | 314.0 | 2498.0 | 394.0 | 2397.0 |
| 15 | 3012.25 | 177.25 | 600.25 | 1813.25 |
| 16 | 1407.25 | 1188.25 | 1849.25 | 1158.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.239 | 0.096 | 0.532 | 0.133 |
| 02 | 0.04 | 0.454 | 0.021 | 0.485 |
| 03 | 0.572 | 0.362 | 0.021 | 0.045 |
| 04 | 0.933 | 0.039 | 0.012 | 0.016 |
| 05 | 0.966 | 0.018 | 0.006 | 0.01 |
| 06 | 0.0 | 0.011 | 0.0 | 0.989 |
| 07 | 0.959 | 0.0 | 0.041 | 0.0 |
| 08 | 0.0 | 0.0 | 0.0 | 1.0 |
| 09 | 0.0 | 0.0 | 0.001 | 0.998 |
| 10 | 0.001 | 0.0 | 0.385 | 0.615 |
| 11 | 0.782 | 0.001 | 0.217 | 0.0 |
| 12 | 0.017 | 0.925 | 0.004 | 0.053 |
| 13 | 0.473 | 0.114 | 0.105 | 0.308 |
| 14 | 0.056 | 0.446 | 0.07 | 0.428 |
| 15 | 0.538 | 0.032 | 0.107 | 0.324 |
| 16 | 0.251 | 0.212 | 0.33 | 0.207 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.045 | -0.957 | 0.754 | -0.626 |
| 02 | -1.816 | 0.596 | -2.466 | 0.661 |
| 03 | 0.827 | 0.369 | -2.441 | -1.716 |
| 04 | 1.316 | -1.843 | -3.039 | -2.712 |
| 05 | 1.35 | -2.591 | -3.605 | -3.218 |
| 06 | -6.477 | -3.117 | -6.477 | 1.374 |
| 07 | 1.343 | -6.477 | -1.79 | -6.477 |
| 08 | -6.477 | -6.477 | -6.477 | 1.385 |
| 09 | -6.477 | -6.096 | -4.928 | 1.384 |
| 10 | -5.606 | -6.096 | 0.43 | 0.899 |
| 11 | 1.139 | -5.429 | -0.141 | -6.096 |
| 12 | -2.65 | 1.307 | -3.945 | -1.542 |
| 13 | 0.636 | -0.783 | -0.866 | 0.209 |
| 14 | -1.49 | 0.578 | -1.264 | 0.537 |
| 15 | 0.765 | -2.057 | -0.845 | 0.258 |
| 16 | 0.005 | -0.164 | 0.277 | -0.19 |
| P-value | Threshold |
|---|---|
| 0.001 | -0.20434 |
| 0.0005 | 1.50046 |
| 0.0001 | 5.00951 |