HAND2.H13CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HAND2.H13CORE.0.P.B
Gene (human)	HAND2 (GeneCards)
Gene synonyms (human)	BHLHA26, DHAND
Gene (mouse)	Hand2
Gene synonyms (mouse)	Dhand, Hed, Thing2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	18
Consensus	bvbvYCTGSnhhnYvTCW
GC content	53.1%
Information content (bits; total / per base)	11.604 / 0.645
Data sources	ChIP-Seq
Aligned words	1022
Previous names	HAND2.H12CORE.0.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (26)	0.871	0.917	0.787	0.859	0.865	0.91	3.359	3.897	167.067	302.004
Mouse	1 (7)	0.863	0.929	0.799	0.885	0.868	0.93	3.657	4.315	131.276	201.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.501	0.498	0.504	0.501	0.503	0.501
Non-Methyl HT-SELEX, 1 experiments	best	0.501	0.498	0.504	0.501	0.503	0.501

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	TWIST {1.2.3.2} (TFClass)
TFClass ID	TFClass: 1.2.3.2.4
HGNC	HGNC:4808
MGI	MGI:103580
EntrezGene (human)	GeneID:9464 (SSTAR profile)
EntrezGene (mouse)	GeneID:15111 (SSTAR profile)
UniProt ID (human)	HAND2_HUMAN
UniProt ID (mouse)	HAND2_MOUSE
UniProt AC (human)	P61296 (TFClass)
UniProt AC (mouse)	Q61039 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	HAND2.H13CORE.0.P.B.pcm
PWM	HAND2.H13CORE.0.P.B.pwm
PFM	HAND2.H13CORE.0.P.B.pfm
Threshold to P-value map	HAND2.H13CORE.0.P.B.thr
Motif in other formats
JASPAR format	HAND2.H13CORE.0.P.B_jaspar_format.txt
MEME format	HAND2.H13CORE.0.P.B_meme_format.meme
Transfac format	HAND2.H13CORE.0.P.B_transfac_format.txt
Homer format	HAND2.H13CORE.0.P.B_homer_format_0.001.txt HAND2.H13CORE.0.P.B_homer_format_0.0005.txt HAND2.H13CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	155.0	264.0	438.0	165.0
02	230.0	182.0	430.0	180.0
03	116.0	310.0	421.0	175.0
04	213.0	180.0	483.0	146.0
05	30.0	346.0	142.0	504.0
06	15.0	987.0	10.0	10.0
07	10.0	4.0	2.0	1006.0
08	4.0	0.0	1006.0	12.0
09	6.0	246.0	601.0	169.0
10	251.0	216.0	184.0	371.0
11	179.0	284.0	123.0	436.0
12	309.0	120.0	78.0	515.0
13	178.0	243.0	276.0	325.0
14	57.0	356.0	69.0	540.0
15	241.0	240.0	412.0	129.0
16	21.0	43.0	24.0	934.0
17	27.0	905.0	8.0	82.0
18	607.0	116.0	19.0	280.0

PFM

	A	C	G	T
01	0.152	0.258	0.429	0.161
02	0.225	0.178	0.421	0.176
03	0.114	0.303	0.412	0.171
04	0.208	0.176	0.473	0.143
05	0.029	0.339	0.139	0.493
06	0.015	0.966	0.01	0.01
07	0.01	0.004	0.002	0.984
08	0.004	0.0	0.984	0.012
09	0.006	0.241	0.588	0.165
10	0.246	0.211	0.18	0.363
11	0.175	0.278	0.12	0.427
12	0.302	0.117	0.076	0.504
13	0.174	0.238	0.27	0.318
14	0.056	0.348	0.068	0.528
15	0.236	0.235	0.403	0.126
16	0.021	0.042	0.023	0.914
17	0.026	0.886	0.008	0.08
18	0.594	0.114	0.019	0.274

PWM

	A	C	G	T
01	-0.495	0.033	0.536	-0.434
02	-0.104	-0.336	0.518	-0.347
03	-0.782	0.192	0.497	-0.375
04	-0.181	-0.347	0.634	-0.555
05	-2.093	0.301	-0.582	0.676
06	-2.733	1.346	-3.088	-3.088
07	-3.088	-3.804	-4.233	1.365
08	-3.804	-5.0	1.365	-2.93
09	-3.505	-0.038	0.851	-0.41
10	-0.018	-0.167	-0.326	0.371
11	-0.353	0.105	-0.724	0.532
12	0.189	-0.748	-1.171	0.698
13	-0.359	-0.05	0.077	0.239
14	-1.477	0.33	-1.291	0.745
15	-0.058	-0.062	0.475	-0.677
16	-2.426	-1.749	-2.302	1.291
17	-2.192	1.26	-3.275	-1.122
18	0.861	-0.782	-2.518	0.091

Standard thresholds

P-value	Threshold
0.001	4.27576
0.0005	5.26361
0.0001	7.30741