KMT2A.H13CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KMT2A.H13CORE.0.P.B
Gene (human)	KMT2A (GeneCards)
Gene synonyms (human)	ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1
Gene (mouse)	Kmt2a
Gene synonyms (mouse)	All1, Hrx, Mll, Mll1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	23
Consensus	CSSvGCYSSSSCYSCSGCYbCSb
GC content	86.92%
Information content (bits; total / per base)	18.946 / 0.824
Data sources	ChIP-Seq
Aligned words	995
Previous names	KMT2A.H12CORE.0.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	36 (223)	0.713	0.83	0.481	0.645	0.658	0.892	2.617	4.379	2.108	16.658

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	CXXC zinc finger factors {2.6} (TFClass)
TF family	CpG-binding {2.6.1} (TFClass)
TF subfamily	{2.6.1.0} (TFClass)
TFClass ID	TFClass: 2.6.1.0.4
HGNC	HGNC:7132
MGI	MGI:96995
EntrezGene (human)	GeneID:4297 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	KMT2A_HUMAN
UniProt ID (mouse)	KMT2A_MOUSE
UniProt AC (human)	Q03164 (TFClass)
UniProt AC (mouse)	P55200 (TFClass)
GRECO-DB-TF	no

ChIP-Seq	36 human, 0 mouse
HT-SELEX	0
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	KMT2A.H13CORE.0.P.B.pcm
PWM	KMT2A.H13CORE.0.P.B.pwm
PFM	KMT2A.H13CORE.0.P.B.pfm
Threshold to P-value map	KMT2A.H13CORE.0.P.B.thr
Motif in other formats
JASPAR format	KMT2A.H13CORE.0.P.B_jaspar_format.txt
MEME format	KMT2A.H13CORE.0.P.B_meme_format.meme
Transfac format	KMT2A.H13CORE.0.P.B_transfac_format.txt
Homer format	KMT2A.H13CORE.0.P.B_homer_format_0.001.txt KMT2A.H13CORE.0.P.B_homer_format_0.0005.txt KMT2A.H13CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	24.0	796.0	112.0	63.0
02	56.0	501.0	342.0	96.0
03	40.0	621.0	300.0	34.0
04	112.0	534.0	257.0	92.0
05	33.0	32.0	831.0	99.0
06	17.0	827.0	79.0	72.0
07	29.0	656.0	94.0	216.0
08	27.0	358.0	535.0	75.0
09	23.0	786.0	113.0	73.0
10	56.0	598.0	270.0	71.0
11	35.0	189.0	723.0	48.0
12	6.0	813.0	109.0	67.0
13	35.0	781.0	85.0	94.0
14	45.0	161.0	692.0	97.0
15	27.0	886.0	52.0	30.0
16	97.0	700.0	101.0	97.0
17	18.0	95.0	795.0	87.0
18	10.0	892.0	49.0	44.0
19	41.0	752.0	49.0	153.0
20	35.0	167.0	533.0	260.0
21	17.0	850.0	101.0	27.0
22	27.0	722.0	164.0	82.0
23	87.0	434.0	355.0	119.0

PFM

	A	C	G	T
01	0.024	0.8	0.113	0.063
02	0.056	0.504	0.344	0.096
03	0.04	0.624	0.302	0.034
04	0.113	0.537	0.258	0.092
05	0.033	0.032	0.835	0.099
06	0.017	0.831	0.079	0.072
07	0.029	0.659	0.094	0.217
08	0.027	0.36	0.538	0.075
09	0.023	0.79	0.114	0.073
10	0.056	0.601	0.271	0.071
11	0.035	0.19	0.727	0.048
12	0.006	0.817	0.11	0.067
13	0.035	0.785	0.085	0.094
14	0.045	0.162	0.695	0.097
15	0.027	0.89	0.052	0.03
16	0.097	0.704	0.102	0.097
17	0.018	0.095	0.799	0.087
18	0.01	0.896	0.049	0.044
19	0.041	0.756	0.049	0.154
20	0.035	0.168	0.536	0.261
21	0.017	0.854	0.102	0.027
22	0.027	0.726	0.165	0.082
23	0.087	0.436	0.357	0.12

PWM

	A	C	G	T
01	-2.276	1.158	-0.79	-1.353
02	-1.468	0.697	0.316	-0.941
03	-1.792	0.911	0.186	-1.947
04	-0.79	0.76	0.032	-0.983
05	-1.976	-2.005	1.201	-0.911
06	-2.593	1.197	-1.132	-1.223
07	-2.098	0.965	-0.962	-0.14
08	-2.166	0.362	0.762	-1.183
09	-2.316	1.146	-0.781	-1.21
10	-1.468	0.873	0.081	-1.237
11	-1.92	-0.273	1.062	-1.617
12	-3.479	1.179	-0.816	-1.293
13	-1.92	1.139	-1.061	-0.962
14	-1.679	-0.431	1.019	-0.931
15	-2.166	1.265	-1.539	-2.066
16	-0.931	1.03	-0.891	-0.931
17	-2.541	-0.951	1.157	-1.038
18	-3.062	1.272	-1.597	-1.701
19	-1.769	1.102	-1.597	-0.482
20	-1.92	-0.395	0.758	0.044
21	-2.593	1.224	-0.891	-2.166
22	-2.166	1.061	-0.413	-1.096
23	-1.038	0.554	0.354	-0.73

Standard thresholds

P-value	Threshold
0.001	2.09521
0.0005	3.24486
0.0001	5.70421