NFE2.H13RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFE2.H13RSNP.1.SM.B
Gene (human)	NFE2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Nfe2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	nhhRbvATGASTCAYn
GC content	43.14%
Information content (bits; total / per base)	16.47 / 1.029
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8780
Previous names	NFE2.H12RSNP.1.SM.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (34)	0.823	0.915	0.757	0.854	0.778	0.894	2.831	3.466	340.767	664.187
Mouse	4 (26)	0.898	0.938	0.832	0.888	0.864	0.923	3.219	3.743	266.367	500.187

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.763	0.782	0.747	0.761	0.744	0.753
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	1.0	0.999	0.999	0.998
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	1.0	0.999	0.999	0.998
Non-Methyl HT-SELEX, 3 experiments	median	0.526	0.564	0.495	0.523	0.489	0.508
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.542	2.657	0.147	0.189

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.756	0.576	0.736	0.534
batch 2	0.808	0.542	0.751	0.491

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	NFE2 {1.1.1.2} (TFClass)
TFClass ID	TFClass: 1.1.1.2.1
HGNC	HGNC:7780
MGI	MGI:97308
EntrezGene (human)	GeneID:4778 (SSTAR profile)
EntrezGene (mouse)	GeneID:18022 (SSTAR profile)
UniProt ID (human)	NFE2_HUMAN
UniProt ID (mouse)	NFE2_MOUSE
UniProt AC (human)	Q16621 (TFClass)
UniProt AC (mouse)	Q07279 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 4 mouse
HT-SELEX	3
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	NFE2.H13RSNP.1.SM.B.pcm
PWM	NFE2.H13RSNP.1.SM.B.pwm
PFM	NFE2.H13RSNP.1.SM.B.pfm
Threshold to P-value map	NFE2.H13RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	NFE2.H13RSNP.1.SM.B_jaspar_format.txt
MEME format	NFE2.H13RSNP.1.SM.B_meme_format.meme
Transfac format	NFE2.H13RSNP.1.SM.B_transfac_format.txt
Homer format	NFE2.H13RSNP.1.SM.B_homer_format_0.001.txt NFE2.H13RSNP.1.SM.B_homer_format_0.0005.txt NFE2.H13RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1983.5	2285.5	2933.5	1577.5
02	1249.25	1414.25	1121.25	4995.25
03	2654.0	4104.0	925.0	1097.0
04	6090.0	622.0	1444.0	624.0
05	187.0	1954.0	2704.0	3935.0
06	1241.0	3909.0	2905.0	725.0
07	7362.0	174.0	1236.0	8.0
08	3.0	35.0	2.0	8740.0
09	0.0	0.0	8617.0	163.0
10	8750.0	29.0	1.0	0.0
11	64.0	4542.0	4125.0	49.0
12	3.0	4.0	38.0	8735.0
13	251.0	8511.0	7.0	11.0
14	8601.0	28.0	127.0	24.0
15	81.25	1983.25	224.25	6491.25
16	1345.75	2104.75	2499.75	2829.75

PFM

	A	C	G	T
01	0.226	0.26	0.334	0.18
02	0.142	0.161	0.128	0.569
03	0.302	0.467	0.105	0.125
04	0.694	0.071	0.164	0.071
05	0.021	0.223	0.308	0.448
06	0.141	0.445	0.331	0.083
07	0.838	0.02	0.141	0.001
08	0.0	0.004	0.0	0.995
09	0.0	0.0	0.981	0.019
10	0.997	0.003	0.0	0.0
11	0.007	0.517	0.47	0.006
12	0.0	0.0	0.004	0.995
13	0.029	0.969	0.001	0.001
14	0.98	0.003	0.014	0.003
15	0.009	0.226	0.026	0.739
16	0.153	0.24	0.285	0.322

PWM

	A	C	G	T
01	-0.101	0.04	0.29	-0.33
02	-0.563	-0.439	-0.671	0.822
03	0.19	0.625	-0.863	-0.693
04	1.02	-1.258	-0.418	-1.255
05	-2.452	-0.116	0.208	0.583
06	-0.569	0.577	0.28	-1.106
07	1.209	-2.523	-0.574	-5.366
08	-6.033	-4.077	-6.243	1.381
09	-6.875	-6.875	1.367	-2.587
10	1.382	-4.252	-6.51	-6.875
11	-3.501	0.727	0.63	-3.758
12	-6.033	-5.859	-3.999	1.38
13	-2.161	1.354	-5.468	-5.109
14	1.365	-4.285	-2.833	-4.427
15	-3.27	-0.101	-2.272	1.084
16	-0.489	-0.042	0.13	0.254

Standard thresholds

P-value	Threshold
0.001	0.54976
0.0005	2.18441
0.0001	5.52951